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KMID : 1206220020090010089
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Journal of Korean Academy of Physical Therapy Science
2002 Volume.9 No. 1 p.89 ~ p.94
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Reduction of muscle cyclooxygenase-2 with transcutaneous electrical nerve stimulation and cold therapy in rats of carrageenan-induced inflammatory muscle pain
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Paek Yun-Woong
Chae Yun-Won
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Abstract
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Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, constitutively expressed cyclooxygenase(COX)-1 and COX-2, which is induced at sites of inflammation. Inhibition of COX-2 is desirable as this may avoid side effects seen with NSAIDs. We examined the effects of transcutaneous electrical nerve stimulation and cold therapy on the levels of muscle cycloooxygenase-2 mRNA in rats of carrageenan-induced inflammatory. The method of behavioral assessment were paw withdrawal latency(PWL) and tail flick test(TFT). The COX-2 mRNA levels were quantified by reverse transcription-polymerase chain reaction (RT-PCR). Following the transcutaneous electrical nerve stimulation and cold therapy, PWL and TFT were increased and COX-2 mRNA expression in gastrocnemius muscles were decreased. These results suggest that a transcutaneous electrical nerve stimulation and cold therapy were good therapy for a muscle pain.
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KEYWORD
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Carrageenan, COX-2, TENS, Cold therapy, RT-PCR
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